Animal models have been used to study tissue induced persistent pain. There are two domains of pain: Acute & Chronic. Many substances have been used to produce the effect of tissue injury; the substances have been categorized based on the domain of pain.

Acute model substances: Carrageenan, Histamine, Acetic Acid, Xylene, Arachidonic acid, Phorbol Myristate Acetate, Myeloperoxidase (MPO), Oxazolone, Formalin.
Chronic model substances: Cotton pellet, Glass rod

Alongside, hypersensitivity pain models have been developed to investigate burning, freezing & irradiation. They are helpful in understanding aspects of inflammatory pain in humans. We provide the means which are essential to understand neuropathic pain and inflammation. Aaranya Biosciences offers a panel of in-vivo pharmacology models of nociception in therapeutic areas of Pain & inflammation.