Metabolic Diseases: A disorder may arise due to the deficiency in the activity of the enzyme/functional gene responsible for the activity. The field has seen a tremendous rise over the last decade and now includes defects in the function of sub cellular organelles.

Diabetes/Obesity/Cardiovascular:
Diabetes mellitus belongs to the group of metabolic disorders of carbohydrate metabolism characterized by high blood glucose levels (hyperglycemia) and usually resulting from insufficient production of the hormone insulin (Type I diabetes) or an ineffective response of cells to insulin (Type II diabetes).  Secreted by the pancreas, insulin is required to transport blood glucose (sugar) into cells.

Diabetes is an important risk factor for cardiovascular disease, as well as a leading cause of adult blindness. Other long-term complications include kidney failure, nerve damage, and lower limb amputation due to impaired circulation. It has been categorized based on insulin dependence as Type I and Type II.

Type I Diabetes is an autoimmune disorder where the body’s immune cells destroy the insulin producing beta cells of pancreas. The resultant outcome is less or no production of insulin. This condition is most often seen in children or young adults. It may become life threatening ultimately leading to coma if left undiagnosed.

Type II Diabetes is caused by the inability of the body to use the insulin produced by the pancreas. This may be referred to as insulin resistance. About 90 to 95 percent of people with diabetes have type 2 which is most often associated with older age, obesity, family history of diabetes, previous history of gestational diabetes, physical inactivity, and certain ethnicities. Aaranya Biosciences specialize in In-vivo high-throughput model systems to profile pre-clinical candidates for treating symptoms caused by Type I and Type II diabetes such as kidney failure, ocular defects, and lipid metabolism defects.

Obesity and overweight in the last decade become a global problem. According to the World Health Organization (WHO) approximately 1.6 billion adults over the age 15+ were identified as overweight.

How is obesity determined? A crude measure of obesity is the body mass index (BMI), a person’s weight (in kilograms) divided by the square of his or her height (in meters). A person with a BMI of 30 or more is generally considered obese & ≥25 is considered overweight.

Obesity is a subject of great concern because of its implications on the health of an individual. It increases the risk of many diseases and health conditions including cardiovascular diseases, type II diabetes, cancers (endometrial, breast, and colon), hypertension, liver and gallbladder disease. These conditions can cause or contribute to premature death and substantial disability. At Aaranya Biosciences we provide high throughput technologies to analyze diet related obesity and other diseases.

Cardiovascular Diseases: The various diseases that fall under the umbrella of heart disease include diseases of blood vessels, such as coronary artery disease; heart rhythm problems (arrhythmias); heart infections; and heart defects. The condition involves narrowing or blockage in blood vessels that can lead to a heart attack, chest pain (angina) or stroke.

At Aaranya biosciences our scientists and technicians are working closely to study the factors associated with metabolic diseases. Our group aims to achieve benefits for people with metabolic diseases or is at risk of developing the disease.