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PK/PD/Toxico-kinetics
PK/PD/Toxico-kinetics

In brief, PK approach characterizes the absorption, distribution, metabolism & dissemination properties of a drug. PD helps in estimating the physiological and biological response to the administered drug. This makes it an indispensable tool in drug development. Together they represent a mathematical & statistical relationship between drug dosage, imminent plasma concentration & effect of drug. PK/PD is the industrial standard for In-silico simulations.

What are the possibilities? They help in creating alternatives-pharmacokinetic hypothesis based on drug effects and population variance.

Toxico-kinetics (TK): In brief, TK provides an estimate assessment of the rate with which a drug which enters along with the relative effect on the body. This niche was only a part of the toxicological assessment but it had gained importance with increasing understanding on the cells internal environment. TK is coupled with PK to understand the effect of drug on the organism.

PK/PD modeling reduces the timeline of trials significantly, by incorporating the data collected in phase I trials can be jump started. The downstream trials can be designed and predicted, it would save a lot of time and money. It’s a very convenient approach to remove redundancies caused by the traditional approach. Delays during clinical trials can add up to the expenses, simulation models helps run test scenario’s, simulate trials and predict trial outcomes.  

At Aaranya Biosciences Private Limited we use latest software modeling to determine proper dose range, route of dosing, formulation, and dosing regimen. They also can be tuned to analyze off-target and on-target effects, drug interactions and other factors including gender, genotype, age, environmental, and drug-drug interactions.






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