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Surgical Skills / Route of Administration / Species / Matrices
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For these studies, surgical expertise is important i.e. animals are cannulated either by jugular or portal or bile or femoral to infuse or administer compound as well as for collection of blood at various time points. Blood or biological fluid collection like bile, urine, feces or tissues is done to understand tissue distribution or organ kinetics as well.

Thirdly compound undergoes first pass metabolism or enterohepatic circulation. To understand this aspect, EHC/Portal/bile cannulated studies are done to collect bile, plasma as well along with urine and feces. These are specialized pK studies to understand mechanism of the compound profile. At Aaranya Biosciences our in house research team is aware of potential adverse effects related to substance administration. Hence we plan study designs with absolute detail to avoid confounding effects to permit accurate interpretation of research findings.

Also, matrices such as blood, organs like liver, adrenal, kidney, brain, testis, ovary, stomach, muscle, bone, pancreas, etc to know exposure. Matrices also include cerebrospinal fluid, Brancheoalvelar fluid, vitreal fluid etc. Organs are with or without perfusion can be collected. Apart from this, surgical ovarectomy, castration etc and studies help to understand PK/PD relationship.

Rodents like rat, mice, guinea pigs, hamsters and large animals like dogs etc can be used for these DMPK studies. Identification of the metabolite/estimate biochemical or preclinical markers can be examined using the above models. Specific prodrugs/NCE/formulation PK studies are also part of the screening process.

  • Computational Chemistry
  • Medicinal Chemistry
  • Molecular Pharmacology
  • DMPK
  • Preformulation
  • Toxicity and Safety Pharmacology
  • Bio-analysis
  • Consulting
  • Disease Models
  • Program Management
  • Integrated Discovery Services
  • Platform Technologies
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